Foetal hypoxia increases cardiac AT2R expression and subsequent vulnerability to adult ischaemic injury

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Foetal hypoxia increases cardiac AT(2)R expression and subsequent vulnerability to adult ischaemic injury.

AIMS Hypoxia is a common stress to the foetus and results in increased cardiac vulnerability to adult ischaemic injury. This study tested the hypothesis that foetal hypoxia causes programming of increased AT(2) receptor (AT(2)R) expression in the heart, resulting in the heightened cardiac susceptibility to adult ischaemic injury. METHODS AND RESULTS Time-dated pregnant rats were divided betwe...

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AIMS the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injury in mammalian heart. We developed and characterized zebrafish cardiac injury induced by hypoxia/reoxygenation (H/R) and the regeneration that followed it. METHODS AND RESULTS adult zebrafish were ...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2010

ISSN: 1755-3245,0008-6363

DOI: 10.1093/cvr/cvq303